ACLS Study Guide

Master the essential concepts, algorithms, medications, ECG rhythms, and emergency protocols covered in Advanced Cardiovascular Life Support. This study guide helps healthcare professionals review key topics for certification, renewal, and clinical practice.

Reading Time

20 Minutes

Last Updated

July 2026

Download

PDF Study Guide

What Is ACLS ?

Advanced Cardiovascular Life Support, commonly known as ACLS, is an advanced emergency response approach for healthcare professionals managing adults with cardiac arrest, acute coronary syndrome, stroke, and other life threatening cardiovascular emergencies. ACLS builds on Basic Life Support and expands clinical skills through cardiac rhythm recognition, advanced airway management, medications, and team-based care.

ACLS uses evidence-based algorithms to guide assessment and treatment according to the patient’s condition. The approach emphasizes early recognition, high-quality CPR, timely defibrillation when indicated, and appropriate care after return of spontaneous circulation

Adult BLS Essentials

Adult Coronary Syndromes and Acute Stroke

Pharmacology in ACLS

Medication

Clinical Use

Adult Dose and Administration

Epinephrine

Supports circulation during cardiac arrest in all rhythms.

Administer 1 mg IV or IO every 3 to 5 minutes throughout cardiac arrest.

Amiodarone

Helps treat VF or pulseless VT that persists after defibrillation.

Deliver 300 mg IV or IO as a bolus; a further 150 mg may be given if necessary.

Atropine

Helps manage symptomatic bradycardia.

Give 1 mg IV every 3 to 5 minutes, up to a maximum total dose of 3 mg.

Adenosine

Can terminate certain regular SVTs and restore a normal rhythm.

Administer 6 mg as a rapid IV push; follow with 12 mg after 1 to 2 minutes if required.

Magnesium Sulfate

Supports treatment of torsades de pointes and hypomagnesemia.

Infuse 1 to 2 g IV, diluted in 10 mL of D5W, over 5 to 20 minutes, according to the clinical indication.

Dopamine

Provides circulatory support when symptomatic bradycardia or hypotension does not respond adequately to atropine.

Start an IV infusion at 0.05 to 1 mcg/kg/min and adjust according to the patient’s response.

Norepinephrine

Helps restore blood pressure and perfusion during severe hypotension and shock.

Begin at 0.1 to 0.5 mcg/kg/min, then adjust the infusion rate as clinically indicated.

Aspirin

Reduces platelet activity in acute coronary syndrome.

Provide 81 to 325 mg orally, preferably chewed when appropriate.

Nitroglycerin

Relieves ischemic chest discomfort associated with acute coronary syndrome.

Place 0.4 mg sublingually every 5 minutes, with no more than 3 doses.

ACLS Algorithms

Cardiac arrest is managed according to whether the initial rhythm is shockable or nonshockable. Rapid rhythm recognition helps determine whether defibrillation should be delivered or whether CPR and medication therapy should begin immediately.

Shockable Rhythms: VF / pVT

For ventricular fibrillation or pulseless ventricular tachycardia, defibrillation is the primary treatment. Follow each shock with 2 minutes of CPR and reassess the rhythm, adding medications according to the algorithm.

  1. Deliver a shock.
  2. Continue CPR for 2 minutes.
  3. If the rhythm remains shockable, deliver another shock, then continue CPR for 2 minutes while administering epinephrine every 3 to 5 minutes.
  4. If VF or pVT persists, deliver another shock and continue CPR for 2 minutes. Administer amiodarone or lidocaine according to the algorithm.
  5. Identify and treat reversible causes, including the Hs and Ts.

Nonshockable Rhythms: Asystole / PEA

Asystole and pulseless electrical activity are nonshockable rhythms, so treatment focuses on immediate CPR, epinephrine, and correction of reversible causes.

  1. Begin CPR immediately.
  2. Establish IV or IO access.
  3. Administer epinephrine 1 mg IV or IO as soon as possible, then repeat every 3 to 5 minutes.
  4. Identify and treat reversible causes, including the Hs and Ts.

Bradycardia with a pulse requires evaluation for symptoms, hemodynamic instability, and possible reversible causes. Treatment depends on the patient’s clinical condition and response to initial therapy.

  1. Evaluate the patient for cardiopulmonary compromise and identify reversible causes.
  2. Administer atropine 1 mg IV.
  3. Repeat atropine every 3 to 5 minutes as needed, up to a maximum total dose of 3 mg.
  4. If atropine is ineffective, consider transcutaneous pacing.
  5. If needed, start a dopamine infusion at 5 to 20 mcg/kg/min or an epinephrine infusion at 2 to 10 mcg/min.

Tachycardia with a pulse is managed based on whether the patient is stable or showing signs of cardiopulmonary compromise. QRS width and rhythm regularity also help determine the appropriate treatment approach.

Stable

  1. Evaluate hemodynamic stability and determine whether the QRS is narrow or wide.
  2. For a regular narrow QRS rhythm, try vagal maneuvers first. If the rhythm persists, administer adenosine 6 mg by rapid IV push, followed by 12 mg if needed.
  3. For stable, regular monomorphic wide QRS tachycardia, adenosine may be considered when appropriate. An antiarrhythmic infusion and expert consultation may also be needed.
  4. Identify and treat the underlying cause of the tachycardia.

Unstable

  1. Perform synchronized cardioversion immediately when tachycardia is causing significant cardiopulmonary compromise.

The Acute Coronary Syndrome algorithm focuses on quickly identifying myocardial ischemia, supporting the patient, and restoring coronary blood flow when needed.

  1. Obtain a 12-lead ECG as soon as possible to identify signs of acute myocardial ischemia or infarction.
  2. Administer aspirin when indicated and when there are no contraindications. Provide supplemental oxygen only when the patient is hypoxemic.
  3. For STEMI, use primary PCI when it can be performed promptly. If timely PCI is not possible and the patient is eligible, give fibrinolytic therapy.

The stroke algorithm focuses on rapid recognition, prompt imaging, and timely treatment to reduce neurological injury.

  1. Recognize possible stroke symptoms using the FAST approach and note when symptoms began or when the patient was last known well.
  2. Obtain an urgent noncontrast CT scan to determine whether intracranial bleeding is present and guide treatment decisions.
  3. Consider thrombolytic therapy for eligible patients with acute ischemic stroke after appropriate evaluation and exclusion of intracranial bleeding.

ECG Rhythm : Recognition

Key ECG Components

The key ECG components help identify the heart’s electrical activity and recognize different cardiac rhythms.

Heart Block Levels

Heart blocks occur when electrical signals from the atria are delayed or blocked before reaching the ventricles. The severity can range from a slight delay in conduction to complete failure of the signals to reach the ventricles.

Heart Rhythm

Rhythm

Description

ECG Appearance

Normal Sinus Rhythm

Heart rate of 60 to 100 bpm with consistent rhythm intervals.

Evenly spaced QRS complexes with normal morphology.

Bradycardia

Heart rate of less than 60 bpm in sinus bradycardia.

Widely spaced normal QRS complexes.

Tachycardia

Heart rate of more than 100 bpm in sinus tachycardia.

Closely spaced normal QRS complexes.

Atrial Fibrillation (AF)

No distinct P waves with an irregularly irregular ventricular response.

Irregularly irregular rhythm with no clear P waves. 

Ventricular Fibrillation (VF)

Chaotic ventricular electrical activity with no effective cardiac contraction.

Disorganized, irregular waveform.

Asystole

No detectable cardiac electrical activity.

Flat line after confirming proper lead connection and equipment function.

Team Dynamics

Effective team dynamics help healthcare providers coordinate their actions, communicate clearly, and maintain organized care during resuscitation. Strong teamwork also supports timely decisions and consistent patient care.

Leadership

Take charge of the resuscitation, provide clear direction, and keep the team focused on the patient's needs.

Communication

Share information clearly, give concise instructions, and confirm that important messages are understood.

Role assignment

Give each team member a specific responsibility to maintain an organized response and avoid confusion during care.

Knowledge sharing

Communicate relevant findings, changes in the patient's condition, and treatment updates with the team throughout the resuscitation.

Situational awareness

Remain aware of the patient's condition, team performance, treatment progress, and changes that may require action.

Debriefing after the code

Review the response together, identify areas for improvement, and discuss what worked well to strengthen future resuscitation efforts.

Case scenarios

These scenarios show how ACLS principles are applied to common emergency situations, from cardiac arrest and symptomatic bradycardia to tachycardia and acute stroke.

VF Cardiac Arrest

A patient collapses, has no pulse, and the monitor shows ventricular fibrillation. What should happen first?

    1. Deliver a defibrillation shock immediately when a shockable rhythm is identified.
    2. Continue CPR for 2 minutes after the shock.
    3. Deliver another shock if VF persists; then continue CPR and administer epinephrine every 3 to 5 minutes.
    4. For persistent VF, continue the algorithm with another shock, CPR, and amiodarone or lidocaine.
    5. Identify and treat the Hs and Ts to correct reversible causes.

A patient has a slow heart rate accompanied by symptoms or signs of poor perfusion. What is the first-line treatment?

  1. Evaluate the symptoms and determine whether cardiopulmonary compromise is present.
  2. Administer atropine 1 mg IV as the initial medication.
  3. If atropine is ineffective, consider transcutaneous pacing and/or dopamine or epinephrine infusion.
  4.  

A patient has a rapid heart rate with a pulse. Treatment depends on whether the patient is stable or unstable.

  1. Determine whether the patient is stable or unstable and evaluate the rhythm and QRS width.
  2. For stable, regular, narrow-complex tachycardia, begin with vagal maneuvers
  3. If the rhythm continues, consider adenosine when appropriate.
  4. For unstable tachycardia, perform synchronized cardioversion promptly.
  5.  

Early recognition and treatment can help reduce neurological injury and improve outcomes in patients with acute stroke.

  1. Use the FAST assessment to recognize possible stroke symptoms and determine when the patient was last known well.
  2. Obtain brain imaging, usually a CT scan, to help identify the type of stroke and guide treatment.
  3. Consider IV thrombolysis for eligible patients with acute ischemic stroke after appropriate evaluation.
  4. Evaluate for mechanical thrombectomy when a large vessel occlusion is suspected and the patient meets eligibility criteria.
  5.  

Special Considerations

ACLS care may require additional attention to reversible causes, post-resuscitation care, patient-specific factors, medication safety, and effective team communication.

Identify and treat the Hs and Ts that may be contributing to cardiac arrest or preventing successful resuscitation.

After return of spontaneous circulation, continue close monitoring of airway, breathing, circulation, neurological status, and vital signs to support ongoing stabilization.

Monitor the patient’s temperature and provide appropriate temperature management as part of post-cardiac arrest care.
Once a reliable SpO₂ reading is available after ROSC, adjust oxygen therapy to maintain an oxygen saturation of 90 to 98 %.

Consider patient-specific factors when providing ACLS care, including physiological changes associated with pregnancy and conditions that may affect treatment in older adults.

Verify the medication, dose, route, and timing before administration, while considering contraindications and the patient’s clinical condition.

Use clear communication by giving specific instructions, confirming that the message was understood, and reporting when the task is complete.

Assessment Guide

Preparing for an ACLS assessment is easier when you focus on the core algorithms, rhythm recognition, medications, and clinical decision-making rather than trying to memorize isolated details.

Start with the current ACLS algorithms and understand the sequence of assessment and treatment for each emergency.

Practice identifying common cardiac rhythms and distinguishing shockable from nonshockable rhythms.

Know the main ACLS medications, their indications, doses, and timing within each relevant algorithm.

Work through different patient scenarios to strengthen your ability to apply algorithms and make appropriate treatment decisions.

Pay attention to the key points that determine the next intervention, such as rhythm type, patient stability, and response to treatment.

Review algorithms with flowcharts to visualize the sequence of assessment, intervention, and reassessment.

Practice answering questions within a set time to improve your ability to identify important information and make decisions efficiently.

Review important concepts in shorter sessions and revisit them regularly to strengthen recall and understanding.

ACLS exam quick facts

A few key details can help you understand what to expect from an ACLS course and certification.

BLS proficiency is essential

Strong BLS skills are required before progressing through ACLS training, including high-quality CPR, ventilation, and defibrillation.

Completion

Complete all required course components and meet the applicable assessment requirements to receive ACLS certification.

Certification validity

ACLS certification is generally valid for 2 years before renewal is required.

Course duration

Course time can vary based on the training format and provider, with completion taking approximately 8.25 to 18.5 hours.

Remember

Knowledge, skills, and a calm approach can help healthcare providers respond effectively during emergencies.

EDUCATIONAL USE ONLY:

This content is intended for educational use only. It does not replace an official ACLS course, current ACLS algorithms, local protocols, or professional clinical judgment.

same day cpr logo
powered by bayside cpr

Earn Your AHA ACLS Certification on Your Schedule

ACLS Online & Skills

(Initial & Renewal)

ACLS Skills Only

(Initial & Renewal)

Frequently Asked Questions About ACLS

Who Should Take an ACLS Course?
ACLS training is intended for healthcare professionals who manage or respond to cardiovascular emergencies. Common participants include physicians, nurses, paramedics, respiratory therapists, and other providers working in emergency, critical care, or acute care settings.

Yes. A strong understanding of Basic Life Support is expected before enrolling in an ACLS course. BLS skills such as high-quality CPR, AED use, and basic airway management form the foundation for advanced cardiovascular care.

ACLS certification is generally valid for two years. Renewing your certification helps maintain current knowledge of resuscitation guidelines and reinforces the skills needed to manage cardiovascular emergencies.

Many training providers offer blended learning that combines online coursework with an in-person skills evaluation. Course availability and training formats may vary by certification provider.

Basic Life Support focuses on recognizing life threatening emergencies, performing high-quality CPR, using an AED, and providing basic airway support. Advanced Cardiovascular Life Support builds on these skills by introducing advanced airway management, ECG rhythm interpretation, emergency medications, and evidence-based treatment algorithms.

If your ACLS certification expires, you may be required to complete a renewal or provider course, depending on your employer’s policies and the certification provider’s requirements. Renewing your certification helps keep your knowledge and clinical skills up to date.

No. ACLS is required only for healthcare professionals whose roles involve managing cardiovascular emergencies or providing advanced resuscitation care. Certification requirements vary depending on the employer and clinical setting.